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How to Make a Glycerin-Based Medical Marijuana Tincture

Medical marijuana can come in many forms. A patient can choose his or her preferred method of consumption. Glycerin-based tinctures are very versatile and a great alternative to smoking, vaporizing, or strong-tasting alcohol-based tinctures.

A quality glycerin cannabis tincture can be mixed with any food or beverage and allows patients who need fast relief to place the tincture directly under their tongue. Not only does this method bring fast relief, it also allows patients to control their dosage in a similar manner to smoking their medicine. Although it takes a little time, making your own medical marijuana tincture is a fairly easy process.


Here’s what you will need to get started:
– A crock pot with a “low” and “warm” setting
– Cheesecloth
– Large bowl
– Latex gloves
– Wooden spoon
– 1 gallon of food-grade vegetable glycerin
– 1/4 -1/2 lb of medical marijuana or high quality trim material
– Glass storage container (not pictured)


Combine the vegetable glycerin and the medical marijuana in the crock pot. Stir well with a wooden spoon until all the medical marijuana is saturated with glycerin. Set the crock pot to “low” for approximately 30-45 minutes and stir regularly (every five minutes or so).


After 30-45 minutes you should be able to smell a strong cannabis odor. The medical marijuana will be moistened by the glycerin at this point and should be much darker in color. The odor indicates that the decarboxylation process is occurring. This changes the THCA contained in the cannabis into THC. Once the odor is sensed, turn the crock pot from the “low” setting to the “warm” setting. Cook mixture on the “warm” setting for 18-24 hours, stirring occasionally but vigorously. Stirring will help the glycerin absorb more of the cannabinoids.


After the 18-24 hours (this image was taken after 24 hours) turn off the crock pot and allow mixture to cool for about an hour. This is so you don’t burn your hands during the filtering process. At this point the mixture should appear like a dark, oily soup.


Fold the cheese cloth to fit inside the large bowl. The cheese cloth is used to separate the plant material from the now cannabinoid-rich glycerin.


Spoon some of the mixture into the cheese cloth lined bowl.


Lift up the cheese cloth and squeeze the hell out of it. Please note: a lot of the glycerin gets trapped in the plant material. The harder you can squeeze, the less tincture is wasted.


This is what the freshly squeezed tincture looks like. Transfer the tincture to a glass storage container. Repeat filtering process until all the mixture in the crock pot is strained.


Here’s a half gallon of high quality medical marijuana tincture ready for bottling or long term storage. Larger quantities of the tincture will appear very dark in color even though the tincture is actually a light brown or amber color.


Here is the bottled tincture ready to be shrink wrapped and labeled before being distributed to patients.


A closer look at the finished product. As you can see in the eyedropper the finished product has a beautiful amber color.

This particular tincture recipe yields approximately 115 oz of high quality medicine (there is always some loss during processing). Glycerin has an extremely sweet flavor similar to honey or maple syrup. An average dosage ranges from 15-30 drops (1/4-1/2 tsp) depending on the patient and his or her tolerance. Glycerin tinctures are a great way for patients to medicate wherever and whenever they want. When placed directly under the tongue a patient should feel relief within five minutes.

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